Being in the industry for nearly two decades, Blue Heron Biotech has been cited in multiple publications ranging from academic to pharmaceutical research and development. These are selected scholarly publications citing Blue Heron Biotech gene synthesis, on the practical applications of synthetic genes in drug development and current therapies. All of our gene synthesis products were developed using our proprietary Genemaker® Technology platform.

1. Yang J, Zhou Y, Zhang L et al. Cell Surface Glycoside Hydrolases of Streptococcus gordonii Promote Growth in Saliva. Applied and Environmental Microbiology. 2016;82(17):5278-5286. doi:10.1128/aem.01291-16.

2. Cimica V, Boigard H, Bhatia B et al. Novel Respiratory Syncytial Virus-Like Particle Vaccine Composed of the Postfusion and Prefusion Conformations of the F Glycoprotein. Clinical and Vaccine Immunology. 2016;23(6):451-459. doi:10.1128/cvi.00720-15.

3. Sha J, Kirtley M, Klages C et al. A Replication-Defective Human Type 5 Adenovirus-Based Trivalent Vaccine Confers Complete Protection against Plague in Mice and Nonhuman Primates. Clinical and Vaccine Immunology. 2016;23(7):586-600. doi:10.1128/cvi.00150-16.

4. Bachegowda L, Morrone K, Winski S et al. Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia. Cancer Research. 2016;76(16):4841-4849. doi:10.1158/0008-5472.can-15-3062.

5. Teterina N, Maximova O, Kenney H, Liu G, Pletnev A. MicroRNA-based control of tick-borne flavivirus neuropathogenesis: Challenges and perspectives. Antiviral Research. 2016;127:57-67. doi:10.1016/j.antiviral.2016.01.003.

6. Chen D, Foldvari M. In vitro bioassay model for screening non-viral neurotrophic factor gene delivery systems for glaucoma treatment. Drug Delivery and Translational Research. 2016;6(6):676-685. doi:10.1007/s13346-016-0324-9.

7. Trobridge G, Wu R, Hansen M et al. Cocal-pseudotyped Lentiviral Vectors Resist Inactivation by Human Serum and Efficiently Transduce Primate Hematopoietic Repopulating Cells. Molecular Therapy. 2010;18(4):725-733. doi:10.1038/mt.2009.282.

8. Rogers J, Taylor N, Church G. Biosensor-based engineering of biosynthetic pathways. Current Opinion in Biotechnology. 2016;42:84-91. doi:10.1016/j.copbio.2016.03.005.

9. Hossain A, Heron D, Davenport I et al. Protective effects of bestatin in the retina of streptozotocin- induced diabetic mice. Experimental Eye Research. 2016;149:100-106. doi:10.1016/j.exer.2016.06.016.

10. Cui X, Cao Z, Chen Q, Arjunaraja S, Snow A, Snapper C. Rabbits immunized with Epstein-Barr virus gH/gL or gB recombinant proteins elicit higher serum virus neutralizing activity than gp350. Vaccine. 2016;34(34):4050-4055. doi:10.1016/j.vaccine.2016.06.021.

11. Eirin A, Saad A, Tang H et al. Urinary Mitochondrial DNA Copy Number Identifies Chronic Renal Injury in Hypertensive Patients. Hypertension. 2016;68(2):401-410. doi:10.1161/hypertensionaha.116.07849.

12. Seim I, Jeffery P, Thomas P et al. Multi-species sequence comparison reveals conservation of ghrelin gene-derived splice variants encoding a truncated ghrelin peptide. Endocrine. 2016;52(3):609-617. doi:10.1007/s12020-015-0848-7.

13. Egli A, Lisboa L, O’Shea D et al. Complexity of Host Micro-RNA Response to Cytomegalovirus Reactivation After Organ Transplantation. American Journal of Transplantation. 2015;16(2):650-660. doi:10.1111/ajt.13464.

14. Scallan C, Lindbloom J, Tucker S. Oral Modeling of an Adenovirus-Based Quadrivalent Influenza Vaccine in Ferrets and Mice. Infectious Diseases and Therapy. 2016;5(2):165-183. doi:10.1007/s40121- 016-0108-z.

15. Duthie M, Guderian J, Vallur A et al. Multi-epitope proteins for improved serological detection of Trypanosoma cruzi infection and Chagas Disease. Diagnostic Microbiology and Infectious Disease. 2016;84(3):191-196. doi:10.1016/j.diagmicrobio.2015.11.006.

16. Dobrinić P, Tadić V, Bočkor L et al. Genome Editing Tools for Functional Analysis of HNF1A and IL6ST Genes. Croatica Chemica Acta. 2016;89(2). doi:10.5562/cca2859.

17. Tang Y, Liu J, Fang Q et al. Recombinant Pseudorabies Virus (PRV) Expressing Firefly Luciferase Effectively Screened for CRISPR/Cas9 Single Guide RNAs and Antiviral Compounds. Viruses. 2016;8(4):90. doi:10.3390/v8040090.

18. Tan P, Farrar J, Gaucher E, Miner J. Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout. Molecular Biology and Evolution. 2016;33(9):2193- 2200. doi:10.1093/molbev/msw116.

19. Abraham N, Paul B, Ragnarsson L, Lewis R. Escherichia coli Protein Expression System for Acetylcholine Binding Proteins (AChBPs). PLOS ONE. 2016;11(6):e0157363. doi:10.1371/journal.pone.0157363.

20. O’Flaherty S, Klaenhammer T. Multivalent Chromosomal Expression of the Clostridium botulinum Serotype A Neurotoxin Heavy-Chain Antigen and the Bacillus anthracis Protective Antigen in Lactobacillus acidophilus. Applied and Environmental Microbiology. 2016;82(20):6091-6101. doi:10.1128/aem.01533-16.

20. Motadi L, Moela P. RBBP6: a potential biomarker of apoptosis induction in human cervical cancer cell lines. OncoTargets and Therapy. 2016;Volume 9:4721-4735. doi:10.2147/ott.s100964.

21. Ghose C, Eugenis I, Edwards A, Sun X, McBride S, Ho D. Immunogenicity and protective efficacy of Clostridium difficile spore proteins. Anaerobe. 2016;37:85-95. doi:10.1016/j.anaerobe.2015.12.001.

22. Melo R, Richer L, Johnson D, Gomes-Solecki M. Oral Immunization with OspC Does Not Prevent Tick- Borne Borrelia burgdorferi Infection. PLOS ONE. 2016;11(3):e0151850. doi:10.1371/journal.pone.0151850.

23. Dziegelewska M, Holtze S, Vole C et al. Low sulfide levels and a high degree of cystathionine β- synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat. Redox Biology. 2016;8:192-198. doi:10.1016/j.redox.2016.01.008.

24. Salogiannis J, Egan M, Reck-Peterson S. Peroxisomes move by hitchhiking on early endosomes using the novel linker protein PxdA. The Journal of Cell Biology. 2016;212(3):289-296. doi:10.1083/jcb.201512020.

25. Zhang X, Olsen H, Chen S et al. Anti-CD20 Antibody with Multimerized Fc Domains: A Novel Strategy To Deplete B Cells and Augment Treatment of Autoimmune Disease. The Journal of Immunology. 2015;196(3):1165-1176. doi:10.4049/jimmunol.1501755.

26. Rajagopalan N, Halasz A, Lu Y, Liu E, Monteil-Rivera F, Loewen M. Probing allocrite preferences of 2 naturally occurring variants of the wheat LR34 ABC transporter. Biochemistry and Cell Biology. 2016;94(5):459-470. doi:10.1139/bcb-2016-0058.

27. Ball P. Synthetic biology: Starting from scratch. Nature. 2004;431(7009):624-626. doi:10.1038/431624a.

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